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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1946 2
1947 2
1948 1
1949 4
1952 5
1953 4
1954 1
1955 2
1956 7
1957 5
1958 5
1959 2
1960 2
1961 2
1962 4
1963 1
1964 2
1965 8
1966 3
1967 4
1968 8
1969 12
1970 6
1971 11
1972 19
1973 18
1974 23
1975 72
1976 88
1977 54
1978 92
1979 93
1980 118
1981 142
1982 160
1983 237
1984 263
1985 322
1986 346
1987 363
1988 397
1989 551
1990 800
1991 897
1992 1078
1993 1283
1994 1656
1995 1717
1996 1580
1997 1654
1998 1745
1999 1886
2000 2062
2001 2269
2002 2211
2003 2497
2004 2677
2005 2797
2006 3074
2007 3303
2008 3323
2009 3574
2010 3778
2011 3980
2012 4256
2013 4545
2014 4450
2015 4638
2016 4334
2017 4300
2018 4008
2019 3854
2020 3834
2021 3577
2022 2472
2023 1631
2024 1006

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90,787 results

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Page 1
Signal propagation along the axon.
Rama S, Zbili M, Debanne D. Rama S, et al. Curr Opin Neurobiol. 2018 Aug;51:37-44. doi: 10.1016/j.conb.2018.02.017. Epub 2018 Mar 8. Curr Opin Neurobiol. 2018. PMID: 29525575 Review.
However, while action potentials are generally considered as the quantum of neuronal information, their signaling is not entirely digital. In fact, both their shape and their conduction speed have been shown to be modulated by activity, leading to regulations of synaptic l …
However, while action potentials are generally considered as the quantum of neuronal information, their signaling is not entirely dig …
Signal processing by the endosomal system.
Villaseñor R, Kalaidzidis Y, Zerial M. Villaseñor R, et al. Curr Opin Cell Biol. 2016 Apr;39:53-60. doi: 10.1016/j.ceb.2016.02.002. Epub 2016 Feb 24. Curr Opin Cell Biol. 2016. PMID: 26921695 Free article. Review.
Here, we highlight recent studies revealing a new role of the endosomal network in signal processing. The diversity of entry pathways and endosomal compartments is exploited to regulate the kinetics of receptor trafficking, and interactions with specific signalling …
Here, we highlight recent studies revealing a new role of the endosomal network in signal processing. The diversity of entry pathways …
The alpha,alpha-difluorinated phosphonate L-pSer-analogue: an accessible chemical tool for studying kinase-dependent signal transduction.
Panigrahi K, Eggen M, Maeng JH, Shen Q, Berkowitz DB. Panigrahi K, et al. Chem Biol. 2009 Sep 25;16(9):928-36. doi: 10.1016/j.chembiol.2009.08.008. Chem Biol. 2009. PMID: 19778720 Free PMC article. Review.
This overview focuses on the (alpha,alpha-difluoromethylene)phosphonate mimic of phosphoserine (pCF(2)Ser) and its application to the study of kinase-mediated signal transduction-pathways of great interest to drug development. ...This isopolar, dianionic pSer mimic …
This overview focuses on the (alpha,alpha-difluoromethylene)phosphonate mimic of phosphoserine (pCF(2)Ser) and its application to the study …
Sterol analogue suppresses hedgehog signalling.
Crunkhorn S. Crunkhorn S. Nat Rev Drug Discov. 2024 May;23(5):340. doi: 10.1038/d41573-024-00058-8. Nat Rev Drug Discov. 2024. PMID: 38575782 No abstract available.
Role of thyroid hormone-integrin alphavbeta3-signal and therapeutic strategies in colorectal cancers.
Yang YSH, Ko PJ, Pan YS, Lin HY, Whang-Peng J, Davis PJ, Wang K. Yang YSH, et al. J Biomed Sci. 2021 Apr 8;28(1):24. doi: 10.1186/s12929-021-00719-5. J Biomed Sci. 2021. PMID: 33827580 Free PMC article. Review.
Integrin alphavbeta3 is a plasma membrane structural protein linked to signal transduction pathways that are critical to cancer cell proliferation and metastasis. ...EGFR signal generation and, downstream, transduction of Ras/Raf pathway signals …
Integrin alphavbeta3 is a plasma membrane structural protein linked to signal transduction pathways that are critical to cance …
Molecular Pathways Modulated by Curcumin Analogue, Diarylpentanoids in Cancer.
Paulraj F, Abas F, H Lajis N, Othman I, Naidu R. Paulraj F, et al. Biomolecules. 2019 Jul 10;9(7):270. doi: 10.3390/biom9070270. Biomolecules. 2019. PMID: 31295798 Free PMC article. Review.
The structure of curcumin has thus been used as a lead to design more potent analogues, and diarylpentanoids in particular have shown improved cytotoxicity over curcumin. Investigations of diarylpentanoids have demonstrated that these compounds exert anti-cancer effects th …
The structure of curcumin has thus been used as a lead to design more potent analogues, and diarylpentanoids in particular have shown …
Cell signaling.
Iqbal J, Zaidi M, Avadhani NG. Iqbal J, et al. Ann N Y Acad Sci. 2010 Nov;1211:3-8. doi: 10.1111/j.1749-6632.2010.05811.x. Ann N Y Acad Sci. 2010. PMID: 21062291 Review.
This review explores advances in our understanding of dynamicism in cellular signaling. Areas highlighted include the role of stochasticity in producing diversity in analogous signaling circumstances; population desynchronization's effect in masking newly app …
This review explores advances in our understanding of dynamicism in cellular signaling. Areas highlighted include the role of stochas …
NAADP signaling revisited.
Guse AH, Ernst IM, Fliegert R. Guse AH, et al. Curr Top Med Chem. 2013;13(23):2978-90. doi: 10.2174/15680266113136660212. Curr Top Med Chem. 2013. PMID: 24171770 Review.
Although its Ca2+ releasing activity has been demonstrated in many cell types and in response to different extracellular stimuli, several aspects of NAADP signaling are unclear. This overview focuses on the controversial aspects and reviews NAADP's role as second messenger …
Although its Ca2+ releasing activity has been demonstrated in many cell types and in response to different extracellular stimuli, several as …
Sphingosine-1-phosphate receptors and innate immunity.
Bryan AM, Del Poeta M. Bryan AM, et al. Cell Microbiol. 2018 May;20(5):e12836. doi: 10.1111/cmi.12836. Epub 2018 Mar 23. Cell Microbiol. 2018. PMID: 29498184 Free PMC article. Review.
Sphingosine-1-phosphate (S1P) is a signalling lipid that regulates many cellular processes in mammals. ...Compounds that target S1P signalling pathways are of interest for immune system modulation. Recent studies suggest that S1P signalling regulates many mor …
Sphingosine-1-phosphate (S1P) is a signalling lipid that regulates many cellular processes in mammals. ...Compounds that target S1P …
90,787 results
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